Cannabidiol or cbd for dogs is a phytochemical compound found in cannabis. It is among the handful of naturally occurring phytocannabinoids in plants and is one of the handful of known cannabinoids. This compound has been shown to have a lot of benefits in human health. A recent study published in the Journal of Neuroscience by three major research teams reported that cannabidiol has a neuroprotective effect in human brain tissue. This is the first time that this has been proven.
The three groups of researchers, University of Veterinary Medicine, the University of Veterinary Medicine and the University of Miami School of Medicine, concluded that cannabidiol has a neuroprotective effect on human brain cells implanted in the rat spinal cord. They further concluded that cannabidiol has strong anti-inflammatory and antineoplastic properties, which may help prevent the development of Parkinson’s disease in animals. The study was a clinical trial comparing the effects of using cbd oil (a concentrated form of CBD) in comparison to a placebo. The subjects, which were not allowed to smoke marijuana, had to take the CBD/placebo combination under medical supervision daily. This trial was conducted by the National Institute of Mental Health, University of Nairobi, and the National Cancer Institute, Department of Oncology, College of Veterinary Medicine, University of Miami School of Medicine.
Although this is a significant finding, the ultimate fate of cannabidiol, or CBD, is still unknown. In the clinical trials, CBD and THC (tetrahydrocannabbiturate) were administered at approximately the same time; however, CBD was apparently less potent than THC, thus reducing the likelihood of adverse side effects during the treatment phase. The lack of THC resulted in less severe withdrawal symptoms when the dogs were put under challenge in the clinical trial. Nonetheless, future studies will need to be conducted in larger animal studies to assess the safety and health benefits of CBD for various medical conditions.
Another area of current interest is CBD’s potential health benefits for those with glaucoma, an eye disorder, and serious forms of arthritis. It has been shown in animal studies to effectively reduce intraocular pressure and lessen the effects of glaucoma. There is currently a phase two clinical trial testing CBD in patients diagnosed with the disease, which is scheduled to start in late 2021. Other diseases that have shown promise in the field of pharmaceuticals are pediatric epilepsy, migraine, and pediatric depression. CBD has not received the approval by the US FDA for use as a prescription drug. In Europe, however, the use of CBD for the treatment of brain tumours, seizures, severe pain, nausea, and vomiting, is authorised.
Recently, sativex, another derivative of CBD, was approved by the FDA for use as an aid for intractable pain associated with Crohn’s disease, a disease characterized by rectal bleeding and inflammation. In addition, native is believed to improve appetite and increase the patient’s energy levels. Sativex can also act on both central and peripheral nervous system disorders, including multiple sclerosis, seizures, depression, anxiety, and schizophrenia. Sativex is believed to work through the same mechanism as CBD oil, by interacting with the central nervous system and the endocannabinoid system (the body’s natural response to pain), thereby reducing inflammation and pain.
While CBD may have a number of benefits for patients with certain medical and psychiatric disorders, it should be noted that it is a short term medication and its use should be monitored closely by a qualified physician. It should be noted that although CBD has not been found to be effective in all cases of neurological and psychiatric disorders, such as seizures, it has been found to be effective in the control of spasticity, dystonia, and cataracts in children. However, all patients should be treated with care and should avoid driving while under the influence of CBD oil if possible. Long term use of CBD may result in severe adverse effects on some patients, including loss of appetite, vomiting, increased frequency of diarrhea, decreased ability to retain fluids (especially water), stomach ulcers, weight gain, stiff joints, speech problems, decreased sex drive, increased risk of acquiring infections, tardive dyskinesia, restless legs syndrome, shortness of breath, anxiety, and depression. Therefore, use of the CBD should be carefully monitored by qualified doctors and therapists.